Guthix is a fictional deity from the game RuneScape. Known as the God of balance and nature, Guthix strives for a perfect balance. Considered neither good nor evil, Guthix does both when he needs to balance out the actions Saradomin and Zamorak when either of them tips the scale too far in their own favour. Guthix is immensely powerful, more so than any other god. In principle and practice, he is similar to the Tao of Eastern Religions.

Guthix arrived on RuneScape to find a lost civilization. He reshaped the world of RuneScape and went into a deep "sleep", or as it is described, "A state of meditation which was so intense that he couldn't concentrate on anything else." . In his sleep about a score of other deties tried to rule the land of RuneScape. This is when the God wars occurred and Saradomin and Zamorak usurped the world of Guthix. They would have continued to battle and completely obliterated the world of RuneScape had Guthix not reawakened and prevented them from doing so. He has also made the other gods not to interfere directly with RuneScape affairs. That he has the power to do so proves he is the most powerful god.

Guthix calls the world in which RuneScape is set "Gielinor", the name he christened it with in the beginning. Guthix is often seen as a floating skull with tendrils attached to it but can appear in multiple forms. He has been seen as a multicoloured butterfly and a rock-like object. He has no gender. His true form is impossible to comprehend by mortals. His followers are limited but include the druids, seers, gnomes, and players who choose this path. The dwarves, though not particularly religious, respect Guthix as the source of the metals they mine so diligently. The unique trait about Guthix is that, unlike Zamorak and Saradomin, he does not need followers to remain on the mortal realm but instead draws strength from all living things, showing why he does not demand worship from those who follow his ways.

Taverly is a town completely dedicated to Guthix. He's followed by the Druids of Taverley. Due to his connections with nature they (and chaos druids) are experienced in herblore and some areas of farming. In the Mage Arena, one can get a Guthix Staff to perform the Claws of Guthix spell, a spell that causes a giant purple hand to erupt from the ground and crush the opponent. If a player enters the "Guthix portal" in the castlewars minigame while wearing objects of Saradomin or Zamorak he or she will actually get a small line of dialogue from Guthix stating how he feels sorry for the player's faith in his lesser brothers (Saradomin and Zamorak) and that he will bless the player with some time in the holiest of forms so its wisdom may rub off on the player. At this point during the waiting period the player is turned into a sheep. In his letters on RuneScape.com, Guthix speaks in a dialect of Early Modern English (Such as the kind used In Elizabethean and by Shakespeare) often thought to be middle English.

He and Zamorak also both share followers called chaos druids and chaos druid warriors who follow both Guthix and Zamorak.

For some unknown reason, Guthix gives sheep his protection, and Gnome children mention 'Guthix's Angels', who apparently are all around but cannot be seen.